Publication of IMPRS-LS student Charlotte Blessing

Blessing, C., and Ladurner, A.G.
Nat Struct Mol Biol, [Epub ahead of print].
doi: 10.1038/s41594-020-0412-x

Tickling PARPs into serine action

Poly-(ADP-ribosylation) is a post-translational modification with broad roles in cell signaling. A recently reported crystal structure reveals how the accessory factor HPF1 extends the catalytic active site of PARP1 and PARP2 to promote the specific ADP-ribosylation of serine residues, a prerequisite for dynamic chromatin changes induced by DNA damage.