Publication of IMPRS-LS student Kheewoong Baek

Baek, K., and Schulman, B.A.
Nat Chem Biol, 2019, [Epub ahead of print].
doi: 10.1038/s41589-019-0414-3

Molecular glue concept solidifies

Molecular-glue-mediated proximity-induced degradation now allows unprecedented therapeutic targeting of previously undruggable proteins. Structures showing how aryl-sulfonamides mediate recruitment of the splicing factor RBM39 to the E3 CRL4DCAF15 broaden the mechanistic principles by which molecular glues target ubiquitylation.