Publication of IMPRS-LS student Claudia Gonzalez-Leal

Gonzalez-Leal, C., and Ladurner, A.G.
Mol Cell, 2021, 81, 1367-1369.
doi: 10.1016/j.molcel.2021.03.017

A triskelion of nucleic acids drives protein aggregation in A-T

Mutations in ataxia telangiectasia mutated (ATM) kinase lead to cerebellar neurodegeneration. In this issue of Molecular Cell, Lee et al. (2021) revealed how transcription-induced reactive oxygen species and DNA-RNA hybrids activate PARP enzymes, generating the nucleic acid poly-ADP-ribose, which promotes the accumulation of protein aggregates in A-T-like disorders.