Publication of IMPRS-LS student Xu Zhang

Zhang X, Schnorrer F.
FEBS J. 2017, 284, 1178-1181.

AIDing-targeted protein degradation in Drosophila.

Conditional protein depletion is highly desirable for investigating protein functions in complex organisms. In this issue, Bence and colleagues combined auxin-inducible degradation with CRISPR, establishing an elegant tool to control protein levels. They achieve precise spatio-temporal control of protein degradation during Drosophila oogenesis and early embryogenesis by combining suitable GAL4 drivers (spatial control) with auxin feeding protocols (temporal control).